Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney

Background and Aim : The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and consumption of  l-carnitine on some of the oxidative stress factors in diabetic kidney. Materials and Methods: In this experimental study, 45 male Wistar rats (200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control grou 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic peritoneally injected with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily 100 mg of l-carnitine orally. The aerobic exercise protocol  included five sessions per week on the treadmill. Data were analyzed by two way ANOVA and Tukey post hoc test at P <0.05.  Results: six weeks of aerobic exercise, supplementation of l-carnitine and combined intervention of aerobic exercise and supplementation of l-carnitine do not have a significant effect on MDA and SOD  factors of kidney  tissue in diabetic rats(p>0/05). However, six weeks of aerobic exercise had a significant effect on GPX factor in kidney tissue in diabetic rats(p=0/003). also supplementation   and combined intervention of aerobic exercise and supplementation of  l-carnitine do not have a significant effect on GPX factor of kidney  tissue in diabetic rats(p>0/05) Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on bodys antioxidant defense system and decrease oxidative stress in rats with type 2 diabetes